Teratogenic Activity of Ficus odorata (Blanco) Merr. and Baccaurea tetrandra (Baill.) Müll. in Mice Embryos
Ficus odorata (Blanco) Merr. and Baccaurea tetrandra (Baill.) Müll are indigenous ethnomedicinal plants widely used by the Aetas of Bataan, Philippines for various ailments despite the absence of studies on their possible toxic effect. The study was conducted to assess any teratogenic/antiteratogenic potential of their leaf extracts. Inbred strain of ICR mice were treated with varying concentrations of the crude leaf extracts, with and without the supplementation of 2,500 IU vitamin A, an established teratogen at high concentrations, to determine the teratogenicity or antiteratogenicity of the extracts. Reproductive performance, morphological malformation and skeletal organogenesis of the fetuses were assessed. From the high frequency of congenital abnormalities in the fetuses exposed to F. odorata, the plant has strong potential for teratogenicity. B. tetrandra induced a few malformations, making it a possible weak teratogen. Both plants did not show antiteratogenic activity.
Key Words: teratogenic, Ficus odorata (Blanco) Merr., Baccaurea tetrandra (Baill.) Müll., hypervitaminosis A, reproductive performance, skeletal organogenesis
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